The two men had faced off twice before and talked a lot of trash in the lead-up to the match at T-Mobile Arena in Las Vegas, but Poirier came out on top in the short contest.
McGregor (22-6) and Poirier (28-6) are longtime rivals. In 2014, McGregor defeated Poirier at UFC 178 with a first-round KO. But in January, Poirier got his revenge at UFC 257 with a second-round finish.
Other matches of note
The lightweight bout between Poirier and McGregor was the big draw, but the main card was jam-packed with noteworthy battles.
Sean O’Malley beat Kris Moutinho in the bantamweight in the third round with a TKO, and Tai Tuivasa brought Greg Hardy down in a first-round TKO for the heavyweight match.